Biotin repressor stress
WebJan 1, 2001 · Cooperative association of the Escherichia coli biotin repressor with the biotin operator is allosterically activated by binding of the corepressor, bio-5'-AMP. The corepressor function of... WebThe identity of the biotin repressor and the biotin-apo- BCCP ligase of E. coli was strongly indicated by the very detailed genetic studies of Barker and Campbell (3, 4) who showed that lesions in the same genetic entity, the birA gene, gave rise to both biotin-apoBCCP ligase deficiency and to depression of the biotin operon.
Biotin repressor stress
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WebBiotin is a member of the vitamin B-complex family. Biotin deficiency has been … WebMar 5, 2024 · Biotin biology in E. coli and S. aureus.a BirA is a multi-functional protein …
WebNov 9, 2002 · The Escherichia coli biotin repressor, an allosteric transcriptional regulator, is activated for binding to the biotin operator by the small molecule biotinyl-5‘-AMP. Results of combined thermodynamic, kinetic, and structural studies of the protein have revealed that corepressor binding results in disorder to order transitions in the protein monomer that … WebFeb 13, 1996 · The Escherichia coli repressor of biotin biosynthesis (BirA) is an allosteric site-specific DNA binding protein. The protein is composed of three structural domains. Contact with the biotin operator (bioO) in the transcriptional repression complex is made by the N-terminal domain which contains a helix−turn−helix structural module. The …
WebFeb 1, 1999 · Abstract. Enzymatic attachment of biotin to proteins requires the … WebDec 25, 1982 · A bifunctional protein. Definitive evidence is presented for the bifunctional …
WebMay 15, 2001 · The biotin repressor, BirA, is a critical protein in regulation of biotin retention and biosynthesis in Escherichia coli.Biotin is retained in the cell as a coenzyme that is covalently linked to biotin-dependent carboxylases ().In E. coli this two-step reaction is catalyzed by BirA. The adenylate of biotin is first synthesized from substrates biotin …
WebSep 11, 2014 · Small ligand, bio-5'-AMP, binding and dimerization of the Escherichia coli biotin repressor are allosterically coupled ... Macromolecules Find similar proteins by: (by identity cutoff) 3D Structure Small Molecules Experimental Data & Validation Experimental Data Method: X-RAY DIFFRACTION Resolution: 2.31 Å R-Value Free: 0.218 R-Value … describe the structure of alveoliWebMay 24, 2016 · The paradigm version of BPL is the Escherichia coli BirA that is also a repressor for the biotin biosynthesis pathway. Streptococcus suis, a leading bacterial agent for swine diseases, seems to... chs 7 scanner family peoplesoft bluetoothWebNov 14, 2024 · In this study, we establish OmpR as a global regulator of acid and osmotic stress in S. Typhimurium and E. coli. OmpR represses distinct sets of genes based on the intracellular pH threshold... chs83hd1 templateWebSep 25, 2001 · Diphtheria toxin repressor protein (DtxR) is a 226-amino acid residue, iron-dependent transcriptional regulator of genes in Corynebacterium diphtheriae that code for diphtheria toxin and proteins involved in iron uptake and oxidative stress (1, 2).DtxR is the best characterized member of a family of related proteins from primarily Gram-positive … chs900m2ns5 reviewWeb2 days ago · We found that the expression of genes related to a lytic phage lifestyle in the phage-plasmid were highly up-regulated after the observation of mutations in the repressor sequence, such as the... chs 7m v3 class2レーザーWebNov 4, 2005 · The co-repressor buttresses the dimer interface, resulting in improved packing and a 12 degrees change in the hinge-bending angle along the dimer interface relative to the BirA.biotin structure. This helps explain why the binding of the co-repressor is necessary to optimize the binding of BirA to the bioO operator. describe the structure of a cycloneWebJul 13, 2024 · Stress proteins (SPs) including heat-shock proteins (HSPs), RNA chaperones, and ER associated stress proteins are molecular chaperones essential for cellular homeostasis. The major functions of ... chs7 form