Chondrocyte thrombospondin

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August undefined, 2024

WebIn this study, TNF-α-stimulated porcine and human chondrocyte models were used to investigate the inhibitory effects of Cm-02 and Ck-02 on the molecular mechanisms underlying the anti-OA effects. TNF-α was used to stimulate porcine and human chondrocytes to mimic immunomodulatory potency in-vitro. WebFeb 20, 2024 · Thrombospondin (TSP)‑1 and TSP‑2 are matricellular proteins in the extracellular matrix (ECM), which serve a significant role in the pathological processes of various cardiovascular diseases (CVDs).

Alterations in the chondrocyte surfaceome in response to …

WebA disintegrin and metalloproteinase (ADAM) family members with proteolytic activity may play roles in chondrocyte biology and OA. While regulation of both MMPs and ADAMTS … WebSep 29, 2016 · We evaluated the role of the CXCL12/CXCR4 (C-X-C motif chemokine ligand 12/C-X-C chemokine receptor type 4) axis in aggrecanase-mediated cartilage degradation, and explored the underlying mechanism in a post-traumatic osteoarthritis rat model. Expression of CXCL12/CXCR4 and ADAMTS-5 was analyzed in the knees of … craigslist rentals in monterey ca

Frontiers Thrombospondin-1 Partly Mediates the Cartilage Protective ...

WebCOMP/Thrombospondin-5: Products. COMP (Cartilage Oligomeric Matrix Protein), also known as Thrombospondin-5, is a multidomain calcium binding protein that associates … Webchondrocyte: the major type of cell found in cartilage. Generally encased in a cartilage lacuna. chondroitin sulfate: a sulfated sugar with 40 to 60 repeating units of N -acetylgalactosamine and glucuronic acid, part of the glycosaminoglycan seen in cartilage. WebAbout This Kit. The Human Thrombospondin-1 (Hu TSP-1) ELISA quantitates Hu TSP-1 in human serum or plasma. The assay will exclusively recognize both natural and … craigslist rentals long beach ca

Expression of thrombospondin-1 and its receptor CD36 in …

Proteomic Analyses of Autologous Chondrocyte Implantation …

WebMay 20, 2024 · We thus hypothesized that thrombin may play a critical role as a facilitator of chondrocyte catabolic activity. To test this hypothesis, we cultured rat chondrocytes in … Webtightly coordinated chondrocyte differentiation that cre-ates reserve, proliferating, prehypertrophic, and hyper-trophic cartilage zones in the growth plate. Many human … diy high fiber cerealWebThe majority of its structure and function is controlled by chondrocytes that regulate Extracellular Matrix (ECM) turnover and maintain tissue homeostasis. Imbalance in their function leads to degenerative diseases like Osteoarthritis (OA). OA is characterized by cartilage degradation, osteophyte formation and stiffening of joints. diy highlighting

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Chondrocyte thrombospondin

Chondrocyte responses to neurovascular peptides, …

WebJan 14, 2024 · Chondrocyte swelling and proliferation. ( a) H&E staining of cartilage explants after 2- and 8-day IL-1β treatment. Cell swelling, also termed as fattening, and proliferation can be observed... WebMar 31, 2024 · Some of the most widely used surgical approaches that aim to repair chondral or osteochondral defects of the knee include microfracture and osteotomy. 10,41 Although advanced cell therapy approaches such as autologous chondrocyte implantation (ACI) have been highlighted as more efficacious and cost-effective for repair of chondral …

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WebApr 14, 2024 · These growth factors regulate critical chondrocyte reparative functions by distinct and overlapping signal transduction pathways. ... and measuring the expression of A disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS)-4, ADAMTS-5, matrix metalloproteinase-3 (MMP)-3, MMP-13, and interleukin 6 (IL-6). Unexpectedly, the ... WebAug 30, 2013 · Concentration at which IL-1 is synthesized by chondrocytes is capable of inducing the expression of matrix metalloproteinases (MMPs), aggrecanases, adisintegrin and metalloproteinase with thrombospondin motifs (ADMATs) and other catabolic genes in regions of matrix depletion in OA cartilage . Alterations in the remodeling process of …

WebThis review allows a better understanding of the possible role of LCPUFAs in bone and chondrocyte metabolism as potential therapeutics in combating the pathological complications such as osteoporosis and osteoarthritis. Keywords: Chondrocytes; Long-chain polyunsaturated fatty acids; Osteoblasts; Osteoclasts; PPAR ligands; Prostaglandins. WebJun 26, 2024 · Thrombospondin-1 (TSP-1) is a multifunctional matricellular protein mediating various cell-to-cell and cell-to-matrix …

WebOBJECTIVE Thrombospondin-1 (TSP-1), a trimeric glycoprotein, is involved in cell-matrix interactions of various tissues, particularly in cartilage. Biochemical analyses … WebChondrocyte adhesion to fibronectin or binding to fibronectin fragments also increases the production of cytokines and other catabolic or inflammatory mediators through a mechanism requiring reactive oxygen species (ROS). The specificity of these responses depends on the relative expression of α-integrin subunits on the chondrocyte cell surface.

WebNov 29, 2024 · Figure 1.Expression of THBS1 in chondrocyte and adipose stem cell (ASC) mono- or cocultures. (A) Proteins identified in the secretome of chondrocyte/ASC cocultures significantly differentially secreted in chondrocyte/ASC cocultures as compared to mixed monocultures. The white bars represented the fold change of protein …

WebAbstract Matrix metalloproteinase-7 (MMP-7) is a small proteolytic enzyme that secretes zinc and calcium endopeptidases. It can degrade a variety of extracellular matrix substrates and other substrates and plays important regulatory roles in … diy highlighting capWebApr 11, 2024 · Autologous chondrocyte implantation (ACI) is a cell therapy approach used to treat chondral/osteochondral defects. 10 ACI requires two surgical procedures: in the first (stage 1), cartilage is harvested from a low weightbearing region of the joint, from which chondrocytes are extracted via enzymatic digestion and then culture expanded for 3 to ... craigslist rentals in pahrump nevadaWebApr 24, 1995 · Thrombospondin 1 is present in articular cartilage and is synthesized by chondrocytes. Adult bovine articular chondrocytes in serum-free medium were evaluated in a solid-phase assay for their ability to attach to thrombospondin 1 … craigslist rentals menomonie wi