WebPhase separation is an important mechanism that mediates the compartmentalization of proteins in cells. Proteins that can undergo phase separation in cells share certain typical sequence features, like intrinsically disordered regions (IDRs) and multiple modular domains. Sequence-based analysis tool … Web15 aug. 2024 · 2. The MONET-based modulomic analysis of these crosslinks captured 95 nuclear protein interaction modules (NPIMs), a portion of which contain both the condensate-forming and the intrinsically disordered region (IDR)-containing proteins. …
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Web16 jul. 2024 · Three independent studies published in Science indicate that dynamic IDR–IDR interactions can concentrate transcription regulators on DNA to establish a transcription-competent compartment. Web Relating signal peptide content to intrinsic disorder and biological function. (A) Scatter plot of the fraction of proteins in an over-represented term that contained a signal peptide as a... consumer buying behaviour of jewellery
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Web4 okt. 2024 · Proteins containing a large fraction of intrinsically disordered regions (IDRs), which lack defined 3D structure but often harbor repetitive sequences and low-complexity sequence regions (LCRs), represent another way to mediate multivalent … Web1 okt. 2024 · XopR, an IDR-containing type-III effector protein from Xanthomonas campestris, subverts Arabidopsis actin cytoskeleton dynamics beneath the plasma membrane by interacting with actin and multiple actin-binding proteins and promoting … Web22 mrt. 2024 · Biomolecular condensates (BCs) are formed by proteins with intrinsically disordered regions (IDRs) via liquid–liquid phase separation. Mieap/Spata18, a p53-inducible protein, participates in suppression of colorectal tumors by promoting … consumer buying behaviour theories and models