WebMar 13, 2024 · Necrotizing Enterocolitis (NEC) is characterized by an inflammation of intestinal tissue that primarily affects premature infants. It is the most common and devastating gastrointestinal morbidity of prematurity, but beyond intestinal morbidity, this condition has also been associated with an increased risk of neurodevelopmental delays … WebLactate, under hypoxia, mediates the immunosuppressive effects of efferocytosis by inducing the expression of anti-inflammatory genes (Ref. 39 ). Histone lactylation and immunosurveillance evasion Cancers are featured by the ability of evading immunosurveillance (Ref. 34 ).
The hypoxia–lactate axis tempers inflammation
WebFeb 1, 2024 · Hypoxia- and glycolysis-induced lactate and acidosis suppress inflammatory macrophage activation and promote homeostatic polarization by several mechanisms at … WebFeb 27, 2024 · Notably, lactylation plays a vital role in cancer, inflammation, and regeneration; however, the specific mechanism remains unclear. Histone lactylation … china feed bag company
The hypoxia–lactate axis tempers inflammation - Nature
WebDec 1, 2024 · Hypoxia- and glycolysis-induced lactate and acidosis suppress inflammatory macrophage activation and promote homeostatic polarization by several mechanisms at … WebINFLAMMATION IN 2024 The hypoxia–lactate axis tempers inflammation Lionel B. Ivashkiv Hypoxia and glycolysis have long been appreciated to promote immune cell activation. WebAug 4, 2024 · The hypoxia–lactate axis tempers inflammation. Nat Rev Immunol. 2024;20(2):85–6. Article CAS PubMed PubMed Central Google Scholar Corbet C, Feron O. Tumour acidosis: From the passenger to the driver's seat. Nat Rev Cancer. 2024;17(10):577–93. Article CAS PubMed ... graham aviation