WebApr 12, 2024 · THIO is being developed for patients with NSCLC that have progressed beyond the standard-of-care regimen of existing checkpoint inhibitors. About MAIA Biotechnology, Inc. MAIA is a targeted therapy, immuno-oncology company focused on the development and commercialization of potential first-in-class drugs with novel … WebJul 18, 2024 · CHICAGO, July 18, 2024--MAIA Biotechnology, Inc., a targeted therapy, immuno-oncology company focused on developing potential first-in-class oncology drugs ("MAIA"), announced today that the first ...
MAIA Biotechnology Receives FDA Orphan Drug Designation for THIO …
WebJul 18, 2024 · THIO (6-thio-dG or 6-thio-2’-deoxyguanosine) is an investigational telomere-targeting agent currently in clinical development to evaluate its activity in NSCLC. WebMar 1, 2024 · 2 Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas. 3 Simmons Comprehensive Cancer ... if cell membrane transporters are involved in the cellular uptake of the nucleoside analogue DNA damage mediator 6-thio-2'-deoxyguanosine (6-thio-dG). A large panel of non-small cell … hannes rassi
MAIA Biotechnology Doses First Patient With THIO in Phase 2 Trial (THIO …
WebMay 26, 2024 · Background: The nucleoside analog 5-aza-4’-thio-2’-deoxycytidine (Aza-TdC) inhibits DNA methyltransferase 1 (DNMT1), a methyltransferase involved in methylation … WebJul 13, 2024 · Cisplatin was the only chemotherapy drug received by participants in the trial. Of the 101 participants, hearing loss occurred in 29 (63%) of the children who received cisplatin alone, compared with 18 (33%) of those who also got sodium thiosulfate. Three years after treatment, 98% of the children who received cisplatin and sodium thiosulfate ... WebTesting Algorithm. A red blood cell (RBC) count is performed followed by determined of thiopurine metabolite values by liquid chromatography-tandem mass spectrometry. Values are utilized to calculate and report a final result (unit of measure: pmol/8 x 10 [8] RBC) for 6-thioguanine nucleotides and 6-methylmercaptopurine derivative analyte. hannes snellman liikevaihto